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The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Feng Yun
Fang, Bin
Qiang, Xin Hua
Yu, Tie Ou
Zhong, Jia Rong
Cao, Jun
Zhou, Li Xin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To systematically review the efficacy and potential immunomodulatory effect of ulinastatin combined with thymosin α1 (UTI) for sepsis.
Design.
A systematic review and meta-analysis of randomized controlled trials (RCTs).
Data Sources.
The following databases: PubMed, Embase, and Cochrane Central were searched to identify related clinical trials.
The search terms were “ulinastatin”, “thymosin”, and “sepsis”.
Results.
Six RCTs, 944 septic patients in total, were included in this meta-analysis.
The result shows UTI increased the 28-day survival rate of septic patients, odds ratio (OR) = 2.01, 95% CI [1.53, 2.64].
After the treatment with UTI, the APACHE II score (four studies) dropped 4.72 further, mean = −4.72, 95% CI [−6.54, −2.91] ( p < 0.00001 ).
The mean time of ICU stay (four studies) in UTI group decreased 3.03 days further, mean = −3.03 [−6.99, 0.95] ( p = 0.14 ), and mechanical ventilation time (four studies) decreased 2.05 days, mean = −1.81 [−2.96, −0.66] ( p = 0.002 ).
With the treatment of UTI, CD4+T cells raised 5.13%, mean = 5.13, 95% CI [2.75, 7.50] ( p < 0.0001 ); there was no significant change in CD8+T cells, mean = −0.74 [−2.93, 1.45] ( p = 0.51 ).
Conclusion.
According to this meta-analysis, with the treatment of UTI, the short-term survival rate of septic patients was increased and the illness severity was alleviated.
ICU stay and mechanical ventilation time were effectively shortened.
The beneficial effect of UTI might be due to the potential immunomodulatory effects of these two drugs.
American Psychological Association (APA)
Wang, Feng Yun& Fang, Bin& Qiang, Xin Hua& Yu, Tie Ou& Zhong, Jia Rong& Cao, Jun…[et al.]. 2016. The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099313
Modern Language Association (MLA)
Wang, Feng Yun…[et al.]. The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099313
American Medical Association (AMA)
Wang, Feng Yun& Fang, Bin& Qiang, Xin Hua& Yu, Tie Ou& Zhong, Jia Rong& Cao, Jun…[et al.]. The Efficacy and Immunomodulatory Effects of Ulinastatin and Thymosin α1 for Sepsis: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099313