Hydrogen Peroxide and Sodium Transport in the Lung and Kidney
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Renal and lung epithelial cells are exposed to some significant concentrations of H2O2.
In urine it may reach 100 μM, while in the epithelial lining fluid in the lung it is estimated to be in micromolar to tens-micromolar range.
Hydrogen peroxide has a stimulatory action on the epithelial sodium channel (ENaC) single-channel activity.
It also increases stability of the channel at the membrane and slows down the transcription of the ENaC subunits.
The expression and the activity of the channel may be inhibited in some other, likely higher, oxidative states of the cell.
This review discusses the role and the origin of H2O2 in the lung and kidney.
Concentration-dependent effects of hydrogen peroxide on ENaC and the mechanisms of its action have been summarized.
This review also describes outlooks for future investigations linking oxidative stress, epithelial sodium transport, and lung and kidney function.
American Psychological Association (APA)
Shlyonsky, V.& Boom, A.& Mies, F.. 2016. Hydrogen Peroxide and Sodium Transport in the Lung and Kidney. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099315
Modern Language Association (MLA)
Shlyonsky, V.…[et al.]. Hydrogen Peroxide and Sodium Transport in the Lung and Kidney. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099315
American Medical Association (AMA)
Shlyonsky, V.& Boom, A.& Mies, F.. Hydrogen Peroxide and Sodium Transport in the Lung and Kidney. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099315