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miR-155 as a Biomarker in B-Cell Malignancies
Joint Authors
Due, Hanne
Svendsen, Pernille
Bødker, Julie Støve
Schmitz, Alexander
Bøgsted, Martin
Johnsen, Hans Erik
El-Galaly, Tarec Christoffer
Roug, Anne Stidsholt
Dybkær, Karen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies.
miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies.
The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malignancies using a systematic search strategy to identify relevant literature.
miR-155 was upregulated in several malignancies compared to nonmalignant controls and overexpression of miR-155 was further associated with poor prognosis.
Elevated expression of miR-155 shows potential as a diagnostic and prognostic biomarker in diffuse large B-cell lymphoma and chronic lymphocytic leukemia.
Additionally, in vitro and in vivo studies suggest miR-155 as an efficient therapeutic target, supporting its oncogenic function.
The use of inhibiting anti-miR structures indicates promising potential as novel anticancer therapeutics.
Reports from 53 studies prove that miR-155 has the potential to be a molecular tool in personalized medicine.
American Psychological Association (APA)
Due, Hanne& Svendsen, Pernille& Bødker, Julie Støve& Schmitz, Alexander& Bøgsted, Martin& Johnsen, Hans Erik…[et al.]. 2016. miR-155 as a Biomarker in B-Cell Malignancies. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099316
Modern Language Association (MLA)
Due, Hanne…[et al.]. miR-155 as a Biomarker in B-Cell Malignancies. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1099316
American Medical Association (AMA)
Due, Hanne& Svendsen, Pernille& Bødker, Julie Støve& Schmitz, Alexander& Bøgsted, Martin& Johnsen, Hans Erik…[et al.]. miR-155 as a Biomarker in B-Cell Malignancies. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099316