A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart
Joint Authors
Sala, Valentina
Gatti, Stefano
Gallo, Simona
Medico, Enzo
Cantarella, Daniela
Cimino, James
Ponzetto, Antonio
Crepaldi, Tiziana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries.
Actually, only few models of cardiac cachexia exist.
Difficulties in the recruitment and follow-up of clinical trials implicate that new reproducible and well-characterized animal models are pivotal in developing therapeutic strategies for cachexia.
We generated a new model of cardiac cachexia: a transgenic mouse expressing Tpr-Met receptor, the activated form of c-Met receptor of hepatocyte growth factor, specifically in the heart.
We showed that the cardiac-specific induction of Tpr-Met raises a cardiac hypertrophic remodelling, which progresses into concentric hypertrophy with concomitant increase in Gdf15 mRNA levels.
Hypertrophy progresses to congestive heart failure with preserved ejection fraction, characterized by reduced body weight gain and food intake and skeletal muscle wasting.
Prevention trial by suppressing Tpr-Met showed that loss of body weight could be prevented.
Skeletal muscle wasting was also associated with altered gene expression profiling.
We propose transgenic Tpr-Met mice as a new model of cardiac cachexia, which will constitute a powerful tool to understand such complex pathology and test new drugs/approaches at the preclinical level.
American Psychological Association (APA)
Sala, Valentina& Gatti, Stefano& Gallo, Simona& Medico, Enzo& Cantarella, Daniela& Cimino, James…[et al.]. 2016. A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099319
Modern Language Association (MLA)
Sala, Valentina…[et al.]. A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1099319
American Medical Association (AMA)
Sala, Valentina& Gatti, Stefano& Gallo, Simona& Medico, Enzo& Cantarella, Daniela& Cimino, James…[et al.]. A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099319