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Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
Joint Authors
Chistiakov, Dimitry A.
Ivanova, Ekaterina A.
Bobryshev, Yuri V.
Nikiforov, Nikita G.
Orekhov, Alexander N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles.
Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation.
Moreover, macrophages promote formation of complicated and unstable plaques by maintaining proinflammatory microenvironment.
At the same time, anti-inflammatory macrophages contribute to tissue repair and remodelling and plaque stabilization.
Macrophages therefore represent attractive targets for development of antiatherosclerotic therapy, which can aim to reduce monocyte recruitment to the lesion site, inhibit proinflammatory macrophages, or stimulate anti-inflammatory responses and cholesterol efflux.
More studies are needed, however, to create a comprehensive classification of different macrophage phenotypes and to define their roles in the pathogenesis of atherosclerosis.
In this review, we provide an overview of the current knowledge on macrophage diversity, activation, and plasticity in atherosclerosis and describe macrophage-based cellular tests for evaluation of potential antiatherosclerotic substances.
American Psychological Association (APA)
Bobryshev, Yuri V.& Ivanova, Ekaterina A.& Chistiakov, Dimitry A.& Nikiforov, Nikita G.& Orekhov, Alexander N.. 2016. Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099327
Modern Language Association (MLA)
Bobryshev, Yuri V.…[et al.]. Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1099327
American Medical Association (AMA)
Bobryshev, Yuri V.& Ivanova, Ekaterina A.& Chistiakov, Dimitry A.& Nikiforov, Nikita G.& Orekhov, Alexander N.. Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099327