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Signaling Pathways in Cardiac Myocyte Apoptosis
Joint Authors
Xia, Peng
Liu, Yuening
Cheng, Zhaokang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated with apoptotic death of cardiac myocytes.
Since cardiomyocyte apoptosis is a highly regulated process, pharmacological intervention of apoptosis pathways may represent a promising therapeutic strategy for a number of cardiovascular diseases and disorders including myocardial infarction, ischemia/reperfusion injury, chemotherapy cardiotoxicity, and end-stage heart failure.
Despite rapid growth of our knowledge in apoptosis signaling pathways, a clinically applicable treatment targeting this cellular process is currently unavailable.
To help identify potential innovative directions for future research, it is necessary to have a full understanding of the apoptotic pathways currently known to be functional in cardiac myocytes.
Here, we summarize recent progress in the regulation of cardiomyocyte apoptosis by multiple signaling molecules and pathways, with a focus on the involvement of these pathways in the pathogenesis of heart disease.
In addition, we provide an update regarding bench to bedside translation of this knowledge and discuss unanswered questions that need further investigation.
American Psychological Association (APA)
Xia, Peng& Liu, Yuening& Cheng, Zhaokang. 2016. Signaling Pathways in Cardiac Myocyte Apoptosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1099328
Modern Language Association (MLA)
Xia, Peng…[et al.]. Signaling Pathways in Cardiac Myocyte Apoptosis. BioMed Research International No. 2016 (2016), pp.1-22.
https://search.emarefa.net/detail/BIM-1099328
American Medical Association (AMA)
Xia, Peng& Liu, Yuening& Cheng, Zhaokang. Signaling Pathways in Cardiac Myocyte Apoptosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1099328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099328