Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study
Joint Authors
Chen, Zhe
Zheng, Yuehuan
Yuan, Ye
Jiao, Yucheng
Xiao, Jiaqi
Zhou, Zezhu
Cao, Peng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To investigate whether P.
acnes could induce disc degeneration and Modic changes when inoculated into the discs of rabbits.
Method.
A wild-type strain of P.
acnes isolated from a patient associated with Modic change and disc degeneration was inoculated into the intervertebral discs of rabbits.
Meanwhile, S.
aureus was injected into the discs to establish a model of discitis as the comparison and a standard strain of P.
acnes was inoculated as the control.
MRI and histological change were observed.
Results.
Both the P.
acnes-inoculated and S.
aureus-inoculated rabbits showed hyperintense signals at endplates and hypointense signals at nucleus pulposus on T2WI.
However, P.
acnes only resulted in moderate disc degeneration and endplates rupture in histological examination, which was different from the pathological change of discitis caused by S.
aureus.
In addition, higher death rates (2/3 versus 0/5) were observed in S.
aureus-inoculated rabbits.
Conclusion.
Compared to S.
aureus, the pathological change caused by P.
acnes would be considered as Modic-I change and disc degeneration rather than a discitis.
American Psychological Association (APA)
Chen, Zhe& Zheng, Yuehuan& Yuan, Ye& Jiao, Yucheng& Xiao, Jiaqi& Zhou, Zezhu…[et al.]. 2016. Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099333
Modern Language Association (MLA)
Chen, Zhe…[et al.]. Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099333
American Medical Association (AMA)
Chen, Zhe& Zheng, Yuehuan& Yuan, Ye& Jiao, Yucheng& Xiao, Jiaqi& Zhou, Zezhu…[et al.]. Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099333