![](/images/graphics-bg.png)
Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus niruri L.
Joint Authors
Zheng, Zhi-Zhong
Chen, Liang-Hua
Liu, Shao-Song
Deng, Yuan
Zheng, Guo-Hua
Gu, Yue
Ming, Yan-Lin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phyllanthus niruri L., a well-known medicinal plant, has been used as a folk antitumor remedy in the worldwide scale.
However, the antitumor components in P.
niruri have not been reported.
In order to verify the antitumor components of P.
niruri and the plants which have the high content of these components, we isolated the antitumor components with bioguided fraction and isolation, by different chromatographic methods from the ethyl acetate fraction of P.
niruri., and identified them as ethyl brevifolincarboxylate and corilagin by 1H-NMR, 13C-NMR, 2D-NMR, and mass spectrometric analyses.
Cell cytotoxicity assays showed that corilagin has broad-spectrum antitumor activity, a better antitumor potential, and lower toxicity in normal cells.
Besides, the coefficient of drug interaction (CDI) of 10 μM corilagin and 20 μM cDDP reached up to 0.77, which means corilagin can promote the antitumor activity of cDDP.
Furthermore, by the extensive screening among 10 species of plants reported to contain corilagin, we found that Dimocarpus longan Lour.
has the maximum content of corilagin.
In conclusion, corilagin is the major active antitumor composition in P.
niruri.
L.
on HCC cells and has high content in D.
longan.
American Psychological Association (APA)
Zheng, Zhi-Zhong& Chen, Liang-Hua& Liu, Shao-Song& Deng, Yuan& Zheng, Guo-Hua& Gu, Yue…[et al.]. 2016. Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus niruri L.. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099360
Modern Language Association (MLA)
Zheng, Zhi-Zhong…[et al.]. Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus niruri L.. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099360
American Medical Association (AMA)
Zheng, Zhi-Zhong& Chen, Liang-Hua& Liu, Shao-Song& Deng, Yuan& Zheng, Guo-Hua& Gu, Yue…[et al.]. Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus niruri L.. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099360