Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
Joint Authors
Wang, Xiaoya
Yu, Qin
Yue, Hongmei
Zhang, Jiabin
Zeng, Shuang
Cui, Fenfen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA).
Methods.
A population of 64 with OSA and 24 control subjects was recruited.
Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed.
Results.
Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P<0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P<0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P<0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P<0.01) were higher in OSA group than those in control group.
In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity.
The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r=0.44, P<0.01), AEA and AHI (r=0.52, P<0.01), AEA and HOMA-IR (r=0.62, P<0.01), and 1/2-AG and HOMA-IR (r=0.33, P<0.01).
Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors.
Conclusions.
The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.
American Psychological Association (APA)
Wang, Xiaoya& Yu, Qin& Yue, Hongmei& Zhang, Jiabin& Zeng, Shuang& Cui, Fenfen. 2016. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099383
Modern Language Association (MLA)
Wang, Xiaoya…[et al.]. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099383
American Medical Association (AMA)
Wang, Xiaoya& Yu, Qin& Yue, Hongmei& Zhang, Jiabin& Zeng, Shuang& Cui, Fenfen. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099383