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Clinically Meaningful Use of Blood Tumor Markers in Oncology
Joint Authors
Pagliaro, Lance
Morgenstern, David
Dayyani, Farshid
Holdenrieder, S.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Before the introduction of modern imaging techniques and the recent developments in molecular diagnosis, tumor markers (TMs) were among the few available diagnostic tools for the management of cancer patients.
Easily obtained from serum or plasma samples, TMs are minimally invasive and convenient, and the associated costs are low.
Single TMs were traditionally used but these have come under scrutiny due to their low sensitivity and specificity when used, for example, in a screening setting.
However, recent research has shown superior performance using a combination of multiple TMs as a panel for assessment, or as part of validated algorithms that also incorporate other clinical factors.
In addition, newer TMs have been discovered that have an increased sensitivity and specificity profile for defined malignancies.
The aim of this review is to provide a concise overview of the appropriate uses of both traditional and newer TMs and their roles in diagnosis, prognosis, and the monitoring of patients in current clinical practice.
We also look at the future direction of TMs and their integration with other diagnostic modalities and other emerging serum based biomarkers, such as circulating nucleic acids, to ultimately advance diagnostic performance and improve patient management.
American Psychological Association (APA)
Holdenrieder, S.& Pagliaro, Lance& Morgenstern, David& Dayyani, Farshid. 2016. Clinically Meaningful Use of Blood Tumor Markers in Oncology. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099386
Modern Language Association (MLA)
Holdenrieder, S.…[et al.]. Clinically Meaningful Use of Blood Tumor Markers in Oncology. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099386
American Medical Association (AMA)
Holdenrieder, S.& Pagliaro, Lance& Morgenstern, David& Dayyani, Farshid. Clinically Meaningful Use of Blood Tumor Markers in Oncology. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099386