Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective
Joint Authors
Chen, Guoli
Yang, Zhaohai
Eshleman, James R.
Lin, Ming-Tseh
Netto, George
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Precision medicine, a concept that has recently emerged and has been widely discussed, emphasizes tailoring medical care to individuals largely based on information acquired from molecular diagnostic testing.
As a vital aspect of precision cancer medicine, targeted therapy has been proven to be efficacious and less toxic for cancer treatment.
Colorectal cancer (CRC) is one of the most common cancers and among the leading causes for cancer related deaths in the United States and worldwide.
By far, CRC has been one of the most successful examples in the field of precision cancer medicine, applying molecular tests to guide targeted therapy.
In this review, we summarize the current guidelines for anti-EGFR therapy, revisit the roles of pathologists in an era of precision cancer medicine, demonstrate the transition from traditional “one test-one drug” assays to multiplex assays, especially by using next-generation sequencing platforms in the clinical diagnostic laboratories, and discuss the future perspectives of tumor heterogeneity associated with anti-EGFR resistance and immune checkpoint blockage therapy in CRC.
American Psychological Association (APA)
Chen, Guoli& Yang, Zhaohai& Eshleman, James R.& Netto, George& Lin, Ming-Tseh. 2016. Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1099417
Modern Language Association (MLA)
Chen, Guoli…[et al.]. Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1099417
American Medical Association (AMA)
Chen, Guoli& Yang, Zhaohai& Eshleman, James R.& Netto, George& Lin, Ming-Tseh. Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1099417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099417