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Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System
Joint Authors
Xu, Qing-Qing
Xu, Yi-Jun
Yang, Cong
Tang, Ying
Li, Lin
Cai, Hao-Bin
Hou, Bo-Nan
Chen, Hui-Fang
Wang, Qi
Shi, Xu-Guang
Zhang, Shi-Jie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sodium Tanshinone IIA sulfonate (STS) is a derivative of Tanshinone IIA (Tan IIA).
Tan IIA has been reported to possess neuroprotective effects against Alzheimer’s disease (AD).
However, whether STS possesses effect on AD remains unclear.
This study aims to estimate whether STS could protect against scopolamine- (SCOP-) induced learning and memory deficit in Kunming mice.
Morris water maze results showed that oral administration of STS (10 mg/kg and 20 mg/kg) and Donepezil shortened escape latency, increased crossing times of the original position of the platform, and increased the time spent in the target quadrant.
STS decreased the activity of acetylcholinesterase (AChE) and increased the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice.
Oxidative stress results showed that STS increased the activity of superoxide dismutase (SOD) and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex.
In addition, western blot was carried out to detect the expression of apoptosis related proteins (Bcl-2, Bax, and Caspase-3).
STS upregulated the protein expression of Bcl-2 and downregulated the proteins expression of Bax and Caspase-3.
These results indicated that STS might become a promising therapeutic candidate for attenuating AD-like pathological dysfunction.
American Psychological Association (APA)
Xu, Qing-Qing& Xu, Yi-Jun& Yang, Cong& Tang, Ying& Li, Lin& Cai, Hao-Bin…[et al.]. 2016. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099419
Modern Language Association (MLA)
Xu, Qing-Qing…[et al.]. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099419
American Medical Association (AMA)
Xu, Qing-Qing& Xu, Yi-Jun& Yang, Cong& Tang, Ying& Li, Lin& Cai, Hao-Bin…[et al.]. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099419