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Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis
Joint Authors
Zhang, Lanlan
He, Lixiu
Gong, Jin
Liu, Chuntao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Irreversible airway obstruction (IAO) is a subtype of asthma and relates to poorer prognosis in some asthma patients.
However, the prevalence and risk factors for IAO are unknown.
A systematic review regarding controlled clinical studies (cohort, case-control studies) on IAO asthma in adult and/or children affected by asthma/early wheeze was performed.
Eighteen papers were identified in this study.
It was reported that the incidence of IAO at random effects or fixed effects in severe asthma and nonsevere asthma was 0.54 (95% CI: 0.45–0.62) and 0.16 (95% CI: 0.12–0.20), respectively.
In IAO asthma, the pooled odds ratio (OR) related to smoking exposure was 2.22 (95% CI: 1.82–2.73), the OR for male, smoking, and fractional exhaled nitric oxide (FENO) was 2.22 (95% CI: 1.82–2.7), 1.79 (95% CI: 1.46–2.19), and 2.16 (95% CI: 1.05–4.43), respectively, suggesting these factors increase the risk of IAO.
However, a decreased OR in IAO asthma was observed due to rhinitis (OR = 0.31, 95% CI: 0.24–0.40), atopy (OR = 0.584, 95% CI: 0.466–0.732), and atopic dermatitis (OR = 0.60, 95% CI: 0.42–0.85), indicating these factors are associated with reduced risk of IAO.
IAO in asthma is associated with gender, smoking, FENO, rhinitis, atopy, and atopic dermatitis.
American Psychological Association (APA)
Zhang, Lanlan& He, Lixiu & Gong, Jin& Liu, Chuntao. 2016. Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099423
Modern Language Association (MLA)
Zhang, Lanlan…[et al.]. Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099423
American Medical Association (AMA)
Zhang, Lanlan& He, Lixiu & Gong, Jin& Liu, Chuntao. Risk Factors Associated with Irreversible Airway Obstruction in Asthma: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099423