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High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement
Joint Authors
Chen, Tzu-Ping
Yu, Hsiu-Chin
Huang, Tzu-Yen
Huang, Pin-Fu
Wang, Yao-Chang
Yin, Shun-Ying
Yeh, Chi-Hsiao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
To assess whether the visit-to-visit variability in blood pressure (BP) is a risk factor of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM) 10 years after diagnosis.
Methods.
The electronic medical records of 825 patients, who were diagnosed with type 2 diabetes mellitus (T2DM) during 2000–2002 and regularly followed for 10 years, were retrospectively reviewed.
A total of 53,284 clinic visit records, including analysis of BP, BMI, serum glycohemoglobin, and lipid profile, were analyzed.
Results.
Patients were categorized into two groups according to their visit-to-visit variability in systolic and diastolic BP (SBP and DBP, resp.).
The high-risk group included patients with high SBP and DBP visit-to-visit variability; this group had a 1.679-fold (95% CI: 1.141–2.472, P=0.009) increased risk of PAD compared with patients in the low-risk group.
Cox regression analysis also demonstrated that the age at which the patients were diagnosed with T2DM, smoking status, and mean creatinine level was significantly associated with increased risk of PAD with a hazard ration of 1.064 (95% CI: 1.043–1.084, P<0.001), 1.803 (95% CI: 1.160–2.804, P=0.009), and 1.208 (95% CI: 1.042–1.401, P=0.012), respectively.
Conclusions.
High SBP and DBP visit-to-visit variability is correlated with PAD in the first decade following a diagnosis of T2DM.
American Psychological Association (APA)
Yeh, Chi-Hsiao& Yu, Hsiu-Chin& Huang, Tzu-Yen& Huang, Pin-Fu& Wang, Yao-Chang& Chen, Tzu-Ping…[et al.]. 2016. High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099427
Modern Language Association (MLA)
Yeh, Chi-Hsiao…[et al.]. High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099427
American Medical Association (AMA)
Yeh, Chi-Hsiao& Yu, Hsiu-Chin& Huang, Tzu-Yen& Huang, Pin-Fu& Wang, Yao-Chang& Chen, Tzu-Ping…[et al.]. High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099427