Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease
Joint Authors
Sil, Susmita
Ghosh, Tusharkanti
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The anxiety status is changed along with memory impairments in intracerebroventricular colchicine injected rat model of Alzheimer Disease (cAD) due to neurodegeneration, which has been indicated to be mediated by inflammation.
Inducible cox-2, involved in inflammation, may have important role in the colchicine induced alteration of anxiety status.
Therefore, the present study was designed to investigate the role of cox-2 on the anxiety behavior (response to novelty in an elevated open field space) of cAD by inhibiting it with three different doses (10, 20, and 30 mg) of etoricoxib (a cox-2 blocker) in two time points (14 and 21 days).
The results showed anxiolytic behavior in cAD along with lower serum corticosterone level, both of which were recovered at all the doses of etoricoxib on day 21.
On day 14 all of the anxiety parameters showed similar results to that of day 21 at high doses but not at 10 mg/kg body weight.
Results indicate that the parameters of anxiety were dependent on neuronal circuitries that were probably sensitive to etoricoxib induced blocking of neurodegeneration.
The present study showed that anxiolytic behavior in cADr is predominantly due to cox-2 mediated neuroinflammation induced neurodegeneration in the brain.
American Psychological Association (APA)
Sil, Susmita& Ghosh, Tusharkanti. 2016. Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099429
Modern Language Association (MLA)
Sil, Susmita& Ghosh, Tusharkanti. Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. Behavioural Neurology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099429
American Medical Association (AMA)
Sil, Susmita& Ghosh, Tusharkanti. Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099429