The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers

Joint Authors

Islam, Sardar Mohd. Ashraful
Shahriar, Mohammad
Bhuiyan, Mohiuddin Ahmed
Bin Sayeed, Muhammad Shahdaat
Chowdhury, Zahid Sadek
Morshed, Mohammed Monzur

Source

Behavioural Neurology

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-07-04

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology
Medicine

Abstract EN

Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia.

In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks.

We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB) software to assess the chronic effect of alprazolam.

We selected Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) tests for memory, Rapid Visual Information Processing (RVP) for attention, and Choice Reaction Time (CRT) for psychomotor performance twice: before starting the treatment and after the completion of the treatment.

We found statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS in alprazolam group.

The PAL mean trial to success and total correct matching in 0-second delay, 4-second delay, and all delay situation of DMS were impaired in alprazolam group.

RVP total hits after two weeks of alprazolam treatment were improved in alprazolam group.

But such differences were not observed in placebo group.

In our study, we found that chronic administration of alprazolam affects memory but attentive and psychomotor performance remained unaffected.

American Psychological Association (APA)

Chowdhury, Zahid Sadek& Morshed, Mohammed Monzur& Shahriar, Mohammad& Bhuiyan, Mohiuddin Ahmed& Islam, Sardar Mohd. Ashraful& Bin Sayeed, Muhammad Shahdaat. 2016. The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099441

Modern Language Association (MLA)

Chowdhury, Zahid Sadek…[et al.]. The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers. Behavioural Neurology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099441

American Medical Association (AMA)

Chowdhury, Zahid Sadek& Morshed, Mohammed Monzur& Shahriar, Mohammad& Bhuiyan, Mohiuddin Ahmed& Islam, Sardar Mohd. Ashraful& Bin Sayeed, Muhammad Shahdaat. The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099441

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1099441