The Efficacy and Safety of Antipsychotic Medications in the Treatment of Psychosis in Patients with Parkinson’s Disease
Joint Authors
Divac, Nevena
Medić, Branislava
Prostran, Milica
Stojanović, Radan
Savić Vujović, Katarina
Damjanovic, Aleksandar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Psychotic symptoms are present in up to 50% of patients with Parkinson’s disease.
These symptoms have detrimental effects on patients’ and caregivers’ quality of life and may predict mortality.
The pathogenesis of psychotic symptoms in Parkinson’s disease is complex, but the use of dopaminergic medications is one of the risk factors.
The treatment of psychotic symptoms in Parkinson’s disease is complicated due to the ability of antipsychotic medications to worsen motor symptoms.
The efficacy of clozapine in the treatment of psychosis in patients with Parkinson’s disease has been confirmed in several clinical trials; however, the adverse effects and the necessity of blood count monitoring are the reasons why the use of this drug is challenging.
The studies on safety and efficacy of other antipsychotics conflicting results.
The use of antipsychotics in these patients is also associated with increased mortality.
Psychotic symptoms in Parkinson’s disease per se are also proven predictors of mortality.
Thus it is necessary to treat psychotic symptoms but the choice of an antipsychotic should be based on careful risk/benefit assessment.
Pimavanserin as a novel therapeutic option with more favorable adverse effects profile is now available for this indication, but careful postmarketing monitoring is necessary to establish the true picture of this drug’s long-term safety and efficacy.
American Psychological Association (APA)
Divac, Nevena& Stojanović, Radan& Savić Vujović, Katarina& Medić, Branislava& Damjanovic, Aleksandar& Prostran, Milica. 2016. The Efficacy and Safety of Antipsychotic Medications in the Treatment of Psychosis in Patients with Parkinson’s Disease. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099442
Modern Language Association (MLA)
Divac, Nevena…[et al.]. The Efficacy and Safety of Antipsychotic Medications in the Treatment of Psychosis in Patients with Parkinson’s Disease. Behavioural Neurology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099442
American Medical Association (AMA)
Divac, Nevena& Stojanović, Radan& Savić Vujović, Katarina& Medić, Branislava& Damjanovic, Aleksandar& Prostran, Milica. The Efficacy and Safety of Antipsychotic Medications in the Treatment of Psychosis in Patients with Parkinson’s Disease. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099442