Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice
Joint Authors
Bhar, Kaushik
Chakrabarti, Rajarshi
Siddhanta, Anirban
Das, Subhadip
Chatterjee, Nabanita
Das Saha, Krishna
Bhowmick, Debajit
Mallick, Sanjaya K.
Sarkar, Tuhin Subhra
Source
Biochemistry Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Melanoma is one of the most aggressive forms of cancer, usually resistant to standard chemotherapeutics.
Despite a huge number of clinical trials, any success to find a chemotherapeutic agent that can effectively destroy melanoma is yet to be achieved.
Para-phenylenediamine (p-PD) in the hair dyes is reported to purely serve as an external dyeing agent.
Very little is known about whether p-PD has any effect on the melanin producing cells.
We have demonstrated p-PD mediated apoptotic death of both human and mouse melanoma cells in vitro.
Mouse melanoma tumour growth was also arrested by the apoptotic activity of intraperitoneal administration of p-PD with almost no side effects.
This apoptosis is shown to occur primarily via loss of mitochondrial membrane potential (MMP), generation of reactive oxygen species (ROS), and caspase 8 activation.
p-PD mediated apoptosis was also confirmed by the increase in sub-G0/G1 cell number.
Thus, our experimental observation suggests that p-PD can be a potential less expensive candidate to be developed as a chemotherapeutic agent for melanoma.
American Psychological Association (APA)
Bhowmick, Debajit& Bhar, Kaushik& Mallick, Sanjaya K.& Das, Subhadip& Chatterjee, Nabanita& Sarkar, Tuhin Subhra…[et al.]. 2016. Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099477
Modern Language Association (MLA)
Bhowmick, Debajit…[et al.]. Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice. Biochemistry Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1099477
American Medical Association (AMA)
Bhowmick, Debajit& Bhar, Kaushik& Mallick, Sanjaya K.& Das, Subhadip& Chatterjee, Nabanita& Sarkar, Tuhin Subhra…[et al.]. Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099477