Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation
Joint Authors
Gupta, Amit
Singh, Rajendra
Sonar, Pankaj K.
Saraf, Shailendra K.
Source
Biochemistry Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity.
All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively.
Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 µg/mL.
All the compounds showed moderate-to-good antimicrobial activity.
Compounds 4a [2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-yl)-thiazolidin-4-one] and 4e [3-(4,6-dimethyl-pyrimidin-2-yl)-2-(2-methoxy-phenyl)-thiazolidin-4-one] were the most potent compounds of the series, exhibiting marked antimicrobial activity against Pseudomonas fluorescens, Staphylococcus aureus, and the fungal strains.
Thus, on the basis of results obtained, it may be concluded that synthesized compounds exhibit a broad spectrum of antimicrobial activity.
American Psychological Association (APA)
Gupta, Amit& Singh, Rajendra& Sonar, Pankaj K.& Saraf, Shailendra K.. 2016. Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099497
Modern Language Association (MLA)
Gupta, Amit…[et al.]. Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation. Biochemistry Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099497
American Medical Association (AMA)
Gupta, Amit& Singh, Rajendra& Sonar, Pankaj K.& Saraf, Shailendra K.. Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099497