Fructose-Induced CarbonylOxidative Stress in S. cerevisiae: Involvement of TOR
Joint Authors
Vasylkovska, Ruslana
Valishkevych, Bohdana V.
Lozinska, Liudmyla M.
Semchyshyn, Halyna M.
Source
Biochemistry Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response.
TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated.
Fructose is a more potent glycoxidation agent capable of producing greater amounts of reactive carbonyl (RCS) and oxygen species (ROS) than glucose.
The increased RCS/ROS production, as a result of glycoxidation in vivo, is supposed to be involved in carbonyl/oxidative stress, metabolic disorders, and lifespan shortening of eukaryotes.
In this work we aim to expand our understanding of how TOR is involved in carbonyl/oxidative stress caused by reducing monosaccharides.
It was found that in fructose-grown compared with glucose-grown cells the level of carbonyl/oxidative stress markers was higher.
The defects in the TOR pathway inhibited metabolic rate and suppressed generation of glycoxidation products in fructose-grown yeast.
American Psychological Association (APA)
Valishkevych, Bohdana V.& Vasylkovska, Ruslana & Lozinska, Liudmyla M.& Semchyshyn, Halyna M.. 2016. Fructose-Induced CarbonylOxidative Stress in S. cerevisiae: Involvement of TOR. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099498
Modern Language Association (MLA)
Valishkevych, Bohdana V.…[et al.]. Fructose-Induced CarbonylOxidative Stress in S. cerevisiae: Involvement of TOR. Biochemistry Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099498
American Medical Association (AMA)
Valishkevych, Bohdana V.& Vasylkovska, Ruslana & Lozinska, Liudmyla M.& Semchyshyn, Halyna M.. Fructose-Induced CarbonylOxidative Stress in S. cerevisiae: Involvement of TOR. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099498