Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates
Joint Authors
Evanovich, Eliane
Mendonça-Mattos, Patricia Jeanne de Souza
Harada, Maria Lúcia
Source
Biochemistry Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Glycosyltransferase 6 gene family includes ABO, Ggta1, iGb3S, and GBGT1 genes and by three putative genes restricted to mammals, GT6m6, GTm6, and GT6m7, only the latter is found in primates.
GT6 genes may encode functional and nonfunctional proteins.
Ggta1 and GBGT1 genes, for instance, are pseudogenes in catarrhine primates, while iGb3S gene is only inactive in human, bonobo, and chimpanzee.
Even inactivated, these genes tend to be conversed in primates.
As some of the GT6 genes are related to the susceptibility or resistance to parasites, we investigated (i) the selective pressure on the GT6 paralogs genes in primates; (ii) the basis of the conservation of iGb3S in human, chimpanzee, and bonobo; and (iii) the functional potential of the GBGT1 and GT6m7 in catarrhines.
We observed that the purifying selection is prevalent and these genes have a low diversity, though ABO and Ggta1 genes have some sites under positive selection.
GT6m7, a putative gene associated with aggressive periodontitis, may have regulatory function, but experimental studies are needed to assess its function.
The evolutionary conservation of iGb3S in humans, chimpanzee, and bonobo seems to be the result of proximity to genes with important biological functions.
American Psychological Association (APA)
Evanovich, Eliane& Mendonça-Mattos, Patricia Jeanne de Souza& Harada, Maria Lúcia. 2016. Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099500
Modern Language Association (MLA)
Evanovich, Eliane…[et al.]. Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates. Biochemistry Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099500
American Medical Association (AMA)
Evanovich, Eliane& Mendonça-Mattos, Patricia Jeanne de Souza& Harada, Maria Lúcia. Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099500