The Development of Intensive Care Unit Acquired Hypernatremia Is Not Explained by Sodium Overload or Water Deficit: A Retrospective Cohort Study on Water Balance and Sodium Handling
Joint Authors
Boerma, E. Christiaan
IJzendoorn, M. C. O. van
Navis, G. J.
Kingma, W. Peter
Buter, Hanneke
Source
Critical Care Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
ICU acquired hypernatremia (IAH, serum sodium concentration (sNa) ≥ 143 mmol/L) is mainly considered iatrogenic, induced by sodium overload and water deficit.
Main goal of the current paper was to answer the following questions: Can the development of IAH indeed be explained by sodium intake and water balance? Or can it be explained by renal cation excretion? Methods.
Two retrospective studies were conducted: a balance study in 97 ICU patients with and without IAH and a survey on renal cation excretion in 115 patients with IAH.
Results.
Sodium intake within the first 48 hours of ICU admission was 12.5 [9.3–17.5] g in patients without IAH ( n = 50 ) and 15.8 [9–21.9] g in patients with IAH ( n = 47 ), p = 0.13 .
Fluid balance was 2.3 [1–3.7] L and 2.5 [0.8–4.2] L, respectively, p = 0.77 .
Urine cation excretion (urine Na + K) was < sNa in 99 out of 115 patients with IAH.
Severity of illness was the only independent variable predicting development of IAH and low cation excretion, respectively.
Conclusion.
IAH is not explained by sodium intake or fluid balance.
Patients with IAH are characterized by low urine cation excretion, despite positive fluid balances.
The current paradigm does not seem to explain IAH to the full extent and warrants further studies on sodium handling in ICU patients.
American Psychological Association (APA)
IJzendoorn, M. C. O. van& Buter, Hanneke& Kingma, W. Peter& Navis, G. J.& Boerma, E. Christiaan. 2016. The Development of Intensive Care Unit Acquired Hypernatremia Is Not Explained by Sodium Overload or Water Deficit: A Retrospective Cohort Study on Water Balance and Sodium Handling. Critical Care Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099554
Modern Language Association (MLA)
IJzendoorn, M. C. O. van…[et al.]. The Development of Intensive Care Unit Acquired Hypernatremia Is Not Explained by Sodium Overload or Water Deficit: A Retrospective Cohort Study on Water Balance and Sodium Handling. Critical Care Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099554
American Medical Association (AMA)
IJzendoorn, M. C. O. van& Buter, Hanneke& Kingma, W. Peter& Navis, G. J.& Boerma, E. Christiaan. The Development of Intensive Care Unit Acquired Hypernatremia Is Not Explained by Sodium Overload or Water Deficit: A Retrospective Cohort Study on Water Balance and Sodium Handling. Critical Care Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099554