MEG Connectivity and Power Detections with Minimum Norm Estimates Require Different Regularization Parameters
Joint Authors
Sébastien, Daligault
Hincapié, Ana-Sofía
Kujala, Jan
Delpuech, Claude
Mery, Domingo
Cosmelli, Diego
Jerbi, Karim
Mattout, Jérémie
Source
Computational Intelligence and Neuroscience
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Minimum Norm Estimation (MNE) is an inverse solution method widely used to reconstruct the source time series that underlie magnetoencephalography (MEG) data.
MNE addresses the ill-posed nature of MEG source estimation through regularization (e.g., Tikhonov regularization).
Selecting the best regularization parameter is a critical step.
Generally, once set, it is common practice to keep the same coefficient throughout a study.
However, it is yet to be known whether the optimal lambda for spectral power analysis of MEG source data coincides with the optimal regularization for source-level oscillatory coupling analysis.
We addressed this question via extensive Monte-Carlo simulations of MEG data, where we generated 21,600 configurations of pairs of coupled sources with varying sizes, signal-to-noise ratio (SNR), and coupling strengths.
Then, we searched for the Tikhonov regularization coefficients (lambda) that maximize detection performance for (a) power and (b) coherence.
For coherence, the optimal lambda was two orders of magnitude smaller than the best lambda for power.
Moreover, we found that the spatial extent of the interacting sources and SNR, but not the extent of coupling, were the main parameters affecting the best choice for lambda.
Our findings suggest using less regularization when measuring oscillatory coupling compared to power estimation.
American Psychological Association (APA)
Hincapié, Ana-Sofía& Kujala, Jan& Mattout, Jérémie& Sébastien, Daligault& Delpuech, Claude& Mery, Domingo…[et al.]. 2016. MEG Connectivity and Power Detections with Minimum Norm Estimates Require Different Regularization Parameters. Computational Intelligence and Neuroscience،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099671
Modern Language Association (MLA)
Hincapié, Ana-Sofía…[et al.]. MEG Connectivity and Power Detections with Minimum Norm Estimates Require Different Regularization Parameters. Computational Intelligence and Neuroscience Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1099671
American Medical Association (AMA)
Hincapié, Ana-Sofía& Kujala, Jan& Mattout, Jérémie& Sébastien, Daligault& Delpuech, Claude& Mery, Domingo…[et al.]. MEG Connectivity and Power Detections with Minimum Norm Estimates Require Different Regularization Parameters. Computational Intelligence and Neuroscience. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099671