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Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study
Joint Authors
Benmassaoud, Amine
Xie, Xuanqian
AlYafi, Motaz
Theoret, Yves
Bitton, Alain
Afif, Waqqas
Bessissow, Talat
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Thiopurines are used in the treatment of Crohn’s disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events.
This retrospective study evaluated the safety and efficacy of starting thiopurines at low dose versus full dose in patients with CD and normal TPMT.
Methods.
This was a single center retrospective study including adult CD patients with normal TPMT levels (≥25 nmol/hr/g Hgb) who were followed for 1 year.
Patients started at full dose of azathioprine (2–2.5 mg/kg) or 6-mercaptopurine (1–1.5 mg/kg) were compared to patients started at low dose.
Harvey-Bradshaw index, treatment failure, and drug-related adverse events were recorded.
Results.
Our study included 134 patients.
Both groups had similar incidences of drug-related adverse events and discontinuation of therapy due to side effects.
Fifty-six percent of all adverse events occurred within 31 days and 92% occurred within 3 months of therapy.
Clinical response favored the full-dose group at 6 months (69% versus 27%, p=0.0542).
Conclusions.
Our study indicates that it is safe to start patients on full-dose thiopurine when they have a normal TPMT given its very similar toxicity profile to patients started on low dose.
This may also positively impact efficacy.
American Psychological Association (APA)
Benmassaoud, Amine& Xie, Xuanqian& AlYafi, Motaz& Theoret, Yves& Bitton, Alain& Afif, Waqqas…[et al.]. 2016. Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099834
Modern Language Association (MLA)
Benmassaoud, Amine…[et al.]. Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099834
American Medical Association (AMA)
Benmassaoud, Amine& Xie, Xuanqian& AlYafi, Motaz& Theoret, Yves& Bitton, Alain& Afif, Waqqas…[et al.]. Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099834