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The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease
Joint Authors
Abej, Esmail
Singh, Harminder
Bernstein, Charles N.
El-Matary, Wael
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To determine the relationship between fecal calprotectin (FCAL) and imaging studies and other biochemical inflammatory markers and the impact of FCAL measurements on decision-making in IBD patient management in usual clinical practice.
Methods.
240 persons with IBD were enrolled.
The correlation between FCAL values and other markers for disease activity such as serum albumin (alb), hemoglobin (Hg), and C-reactive protein (CRP) and diagnostic imaging or colonoscopy was examined.
FCAL ≥ 250 mcg/g of stool was considered a positive result indicating active IBD.
Results.
183 stool samples (76.3%) were returned.
The return rate in the pediatric and adult cohorts was 91% ( n = 82 ) and 67.3% ( n = 101 ), respectively ( P < 0.0001 ).
Positive FCAL was associated with colonoscopy findings of active IBD ( P < 0.05 ), low albumin ( P < 0.05 ), anemia ( P < 0.01 ), and elevated CRP ( P < 0.01 ).
There was no significant difference for FCAL results by outcomes on small bowel evaluation among the 21 persons with small bowel CD.
Most persons (87.5%) with normal FCAL and no change in therapy remained in remission during subsequent 3 months.
Conclusions.
FCAL is a useful marker of disease activity and a valuable tool in managing persons with IBD in clinical practice.
Clinicians have to be cautious in interpreting FCAL results in small bowel CD.
American Psychological Association (APA)
Abej, Esmail& El-Matary, Wael& Singh, Harminder& Bernstein, Charles N.. 2016. The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099853
Modern Language Association (MLA)
Abej, Esmail…[et al.]. The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099853
American Medical Association (AMA)
Abej, Esmail& El-Matary, Wael& Singh, Harminder& Bernstein, Charles N.. The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099853