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Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study
Joint Authors
Enns, Robert
Hamm, J.
Gentile, Laura
Gondara, Lovedeep
McGahan, Colleen E.
Telford, Jennifer
Shahidi, Neal
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
The Canadian Partnership Against Cancer (CPAC) recommends a fecal immunochemical test- (FIT-) positive predictive value (PPV) for all adenomas of ≥50%.
We sought to assess FIT performance among average-risk participants of the British Columbia Colon Screening Program (BCCSP).
Methods.
From Nov-2013 to Dec-2014 consecutive participants of the BCCSP were assessed.
Data was obtained from a prospectively collected database.
A single quantitative FIT (NS-Plus, Alfresa Pharma Corporation, Japan) with a cut-off of ≥10 μg/g (≥50 ng/mL) was used.
Results.
20,322 FIT-positive participants underwent CSPY.
At a FIT cut-off of ≥10 μg/g (≥50 ng/mL) the PPV for all adenomas was 52.0%.
Increasing the FIT cut-off to ≥20 μg/g (≥100 ng/mL) would increase the PPV for colorectal cancer (CRC) by 1.5% and for high-risk adenomas (HRAs) by 6.5% at a cost of missing 13.6% of CRCs and 32.4% of HRAs.
Conclusions.
As the NS-Plus FIT cut-off rises, the PPV for CRC and HRAs increases but at the cost of missed lesions.
A cut-off of ≥10 μg/g (≥50 ng/mL) produces a PPV for all adenomas exceeding national recommendations.
Health authorities need to take into consideration endoscopic resources when selecting a FIT positivity threshold.
American Psychological Association (APA)
Shahidi, Neal& Gentile, Laura& Gondara, Lovedeep& Hamm, J.& McGahan, Colleen E.& Enns, Robert…[et al.]. 2016. Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099873
Modern Language Association (MLA)
Shahidi, Neal…[et al.]. Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099873
American Medical Association (AMA)
Shahidi, Neal& Gentile, Laura& Gondara, Lovedeep& Hamm, J.& McGahan, Colleen E.& Enns, Robert…[et al.]. Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099873