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Interval Colorectal Cancers following Guaiac Fecal Occult Blood Testing in the Ontario ColonCancerCheck Program
Joint Authors
Rabeneck, L.
Sutradhar, R.
Tinmouth, J. M.
Baxter, Nancy
Paszat, Lawrence
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
This work examines the occurrence of interval colorectal cancers (CRCs) in the Ontario ColonCancerCheck (CCC) program.
We define interval CRC as CRC diagnosed within 2 years following normal guaiac fecal occult blood testing (gFOBT).
Methods.
Persons aged 50–74 who completed a baseline CCC gFOBT kit in 2008 and 2009, without a prior history of CRC, or recent colonoscopy, flexible sigmoidoscopy, or gFOBT, were identified.
Rates of CRC following positive and normal results at baseline and subsequent gFOBT screens were computed and overall survival was compared between those following positive and normal results.
Results.
Interval CRC was diagnosed within 24 months following the baseline screen among 0.16% of normals and following the subsequent screen among 0.18% of normals.
Interval cancers comprised 38.70% of CRC following the baseline screen and 50.86% following the subsequent screen.
Adjusting for age and sex, the hazard ratio (HR) for death following interval cancer compared to CRC following positive result was 1.65 (1.32, 2.05) following the first screen and 1.71 (1.00, 2.91) following the second screen.
Conclusion.
Interval CRCs following gFOBT screening comprise a significant proportion of CRC diagnosed within 2 years after gFOBT testing and are associated with a higher risk of death.
American Psychological Association (APA)
Paszat, Lawrence& Sutradhar, R.& Tinmouth, J. M.& Baxter, Nancy& Rabeneck, L.. 2016. Interval Colorectal Cancers following Guaiac Fecal Occult Blood Testing in the Ontario ColonCancerCheck Program. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099877
Modern Language Association (MLA)
Paszat, Lawrence…[et al.]. Interval Colorectal Cancers following Guaiac Fecal Occult Blood Testing in the Ontario ColonCancerCheck Program. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099877
American Medical Association (AMA)
Paszat, Lawrence& Sutradhar, R.& Tinmouth, J. M.& Baxter, Nancy& Rabeneck, L.. Interval Colorectal Cancers following Guaiac Fecal Occult Blood Testing in the Ontario ColonCancerCheck Program. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099877