The Utility of Infliximab Therapeutic Drug Monitoring among Patients with Inflammatory Bowel Disease and Concerns for Loss of Response: A Retrospective Analysis of a Real-World Experience
Joint Authors
Enns, Robert
Bressler, Brian
Mitchell, Robert A.
Shuster, Constantin
DeMarco, Mari L.
Rosenfeld, Gregory
Galorport, Cherry
Shahidi, Neal
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Infliximab (IFX) therapeutic drug monitoring (TDM) allows for objective decision making in patients with inflammatory bowel disease (IBD) and loss of response.
Questions remain about whether IFX TDM improves outcomes.
Methods.
Patients with IBD who had IFX TDM due to concerns for loss of response were considered for inclusion.
Serum IFX trough concentration and anti-drug antibody (ADA) concentrations were measured.
Patients were grouped by TDM results: group 1, low IFX/high ADA; group 2, low IFX/low ADA; group 3, therapeutic IFX.
Changes in management were analyzed according to groupings; remission rates were assessed at 6 months.
Results.
71 patients were included of whom 37% underwent an appropriate change in therapy.
Groups 1 (67%) and 2 (83%) had high adherence compared to only 9% in group 3.
At 6 months, 57% had achieved remission.
More patients who underwent an appropriate change in therapy achieved remission, though this did not reach statistical significance (69% versus 49%; P=0.098).
Conclusions.
A trend towards increased remission rates was associated with appropriate changes in management following TDM results.
Many patients with therapeutic IFX concentrations did not undergo an appropriate change in management, potentially reflecting a lack of available out-of-class options at the time of TDM or due to uncertainty of the meaning of the reported therapeutic range.
American Psychological Association (APA)
Mitchell, Robert A.& Shuster, Constantin& Shahidi, Neal& Galorport, Cherry& DeMarco, Mari L.& Rosenfeld, Gregory…[et al.]. 2016. The Utility of Infliximab Therapeutic Drug Monitoring among Patients with Inflammatory Bowel Disease and Concerns for Loss of Response: A Retrospective Analysis of a Real-World Experience. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099884
Modern Language Association (MLA)
Mitchell, Robert A.…[et al.]. The Utility of Infliximab Therapeutic Drug Monitoring among Patients with Inflammatory Bowel Disease and Concerns for Loss of Response: A Retrospective Analysis of a Real-World Experience. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099884
American Medical Association (AMA)
Mitchell, Robert A.& Shuster, Constantin& Shahidi, Neal& Galorport, Cherry& DeMarco, Mari L.& Rosenfeld, Gregory…[et al.]. The Utility of Infliximab Therapeutic Drug Monitoring among Patients with Inflammatory Bowel Disease and Concerns for Loss of Response: A Retrospective Analysis of a Real-World Experience. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099884