Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH
Joint Authors
Wan, Xingyong
Xu, Chengfu
Yu, Chaohui
Li, Youming
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide.
Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma.
The pathogenesis of disease progression from NAFLD to NASH has not been fully understood.
Immunological mechanisms that have been increasingly recognized in the disease progression include defects in innate immunity, adaptive immunity, Toll-like receptor (TLR) signaling, and gut-liver axis.
The NLRP3 inflammasome is an intracellular multiprotein complex involved in the production of mature interleukin 1-beta (IL-1β) and induces metabolic inflammation.
NLRP3 inflammasome has been recently demonstrated to play a crucial role in the progression of NASH.
This review highlights the recent findings linking NLRP3 inflammasome to the progression of NASH.
American Psychological Association (APA)
Wan, Xingyong& Xu, Chengfu& Yu, Chaohui& Li, Youming. 2016. Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099904
Modern Language Association (MLA)
Wan, Xingyong…[et al.]. Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099904
American Medical Association (AMA)
Wan, Xingyong& Xu, Chengfu& Yu, Chaohui& Li, Youming. Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099904