Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications
Joint Authors
Richter, James M.
Arshi, Nabeela K.
Oster, Gerry
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Ulcerative proctitis (UP) is typically treated initially with oral 5-aminosalicylate (“5-ASA”), mesalamine suppository, or mesalamine enema (“UP Rx”).
Little is known about their effectiveness in practice.
Methods.
Using a US health insurance database, we identified new-onset UP patients between January 1, 2005, and December 31, 2007, based on the following: (1) initiation of UP Rx; (2) endoscopy in prior 30 days resulting in diagnosis of UP; and (3) no prior encounters for ulcerative colitis or Crohn’s disease.
We examined the incidence of therapy escalation and total costs in relation to initial UP Rx.
Results.
We identified 548 patients: 327 received mesalamine suppository, 138 received oral 5-ASA, and 83 received mesalamine enema, as initial UP Rx.
One-third receiving oral 5-ASA experienced therapy escalation over 12 months, 21% for both mesalamine suppository and enema.
Mean cumulative total cost of UP Rx over 12 months was $1552, $996, and $986 for patients beginning therapy with oral 5-ASA, mesalamine enema, and mesalamine suppository, respectively.
Contrary to expert recommendations the treatments were often not continued prophylactically.
Conclusions.
Treatment escalation was common, and total costs of therapy were higher, in patients who initiated treatment with oral 5-ASA.
Further study is necessary to assess the significance of these observations.
American Psychological Association (APA)
Richter, James M.& Arshi, Nabeela K.& Oster, Gerry. 2016. Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099906
Modern Language Association (MLA)
Richter, James M.…[et al.]. Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099906
American Medical Association (AMA)
Richter, James M.& Arshi, Nabeela K.& Oster, Gerry. Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099906