Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy
Joint Authors
Oo, Ye H.
Than, Nwe Ni
Jeffery, Hannah C.
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autoimmune hepatitis (AIH) is an immune mediated liver injury.
The precise aetiology of AIH is still unknown but current evidence suggests both genetic and environmental factors are involved.
Breakdown in peripheral self-tolerance, and impaired functions of FOXP3+ regulatory T cell along with effector cell resistance to suppression at the tissue level seem to play an important role in AIH immunopathogenesis.
AIH is predominantly a T lymphocytes driven disease but B lymphocytes are also involved in the immunopathology.
Innate immune cells are crucial in the initial onset of disease and their response is followed by adaptive T (Th1, Th17, and cytotoxic T cells) and B cell responses evidenced by liver histology and peripheral blood serology.
Standard treatment regimens involving steroid and immunosuppressive medications lead to global immune suppression requiring life-long therapy with many side effects.
Biologic therapies have been attempted but duration of remission is short-lived.
Future direction of diagnosis and treatment for AIH should be guided by “omics” and the immunology profile of the individual patient and clinicians should aim to deliver personalised medicine for their patients.
Cell therapy such as infusion of autologous, antigen-specific, and liver-homing regulatory T cells to restore hepatic immune tolerance may soon be a potential future treatment for AIH patients.
American Psychological Association (APA)
Than, Nwe Ni& Jeffery, Hannah C.& Oo, Ye H.. 2016. Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1099911
Modern Language Association (MLA)
Than, Nwe Ni…[et al.]. Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1099911
American Medical Association (AMA)
Than, Nwe Ni& Jeffery, Hannah C.& Oo, Ye H.. Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1099911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099911