VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma
Joint Authors
Pinhel, Marcela A. S.
de Godoy, Moacir Fernandes
Souza, Dorotéia R. S.
Fucuta Pereira, Patrícia
Baitello, Maria Eduarda Lopes
Tenani, Graciele Domitila
Ferreira, Rafael Fernandes
Nogueira, Victor
da Silva, Rita de Cássia Martins Alves
Silva, Renato Ferreira da
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the most common primary neoplasia of the liver.
Major risk factors for hepatocellular carcinoma include chronic liver diseases, carcinogenic agents, and genetic alterations as well as vascular endothelial growth factor (VEGF) involved in angiogenesis process.
The aim of this study was to evaluate the association of VEGF-A (C936T and A1154G) with HCC and cirrhosis, in addition to serum levels of VEGF, clinical profile, lifestyle habits, and comorbidities.
A total of 346 individuals were studied: 102 with HCC (G1), 117 with cirrhosis (G2), and 127 controls (G3).
Polymorphisms were analysed by PCR/RFLP and serum levels of VEGF by ELISA.
Alpha error was set at 5%.
The wild-type genotype of both polymorphisms prevailed ( P > 0.05 ).
In G1, 23% of the patients died, with no relation to genetic profile ( P > 0.05 ).
Increased VEGF level was observed in G1 and G3, related to the mutant allele of VEGF-C936T and VEGF-A1154G, respectively, and compared with the wild-type genotype ( P = 0.0285 ; P = 0.0284 , resp.) as well as G1 versus G2 and G3 for VEGF-C936T and G1 versus G2 for VEGF-A1154G ( P < 0.05 for both).
In conclusion, there is a relationship between mutant alleles of VEGF-C936T and VEGF-A1154G polymorphisms and higher VEGF level, making them potential markers for HCC.
American Psychological Association (APA)
Baitello, Maria Eduarda Lopes& Tenani, Graciele Domitila& Ferreira, Rafael Fernandes& Nogueira, Victor& Pinhel, Marcela A. S.& da Silva, Rita de Cássia Martins Alves…[et al.]. 2016. VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099962
Modern Language Association (MLA)
Baitello, Maria Eduarda Lopes…[et al.]. VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099962
American Medical Association (AMA)
Baitello, Maria Eduarda Lopes& Tenani, Graciele Domitila& Ferreira, Rafael Fernandes& Nogueira, Victor& Pinhel, Marcela A. S.& da Silva, Rita de Cássia Martins Alves…[et al.]. VEGF Polymorphisms Related to Higher Serum Levels of Protein Identify Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099962