Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa
Joint Authors
Sonmezer, Meliha Cagla
Ertem, Gunay
Erdinc, Fatma Sebnem
Kaya Kilic, Esra
Adiloglu, Ali
Hatipoglu, Cigdem
Tulek, N.
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Pseudomonas aeruginosa (P.
aeruginosa) is resistant to various antibiotics and can cause serious nosocomial infections with high morbidity and mortality.
In this clinical study, we investigated the risk factors in patients who were diagnosed with P.
aeruginosa-related nosocomial infection.
Methods.
A retrospective case control study including patients with P.
aeruginosa-related nosocomial infection.
Patients who were resistant to any of the six antibiotics (imipenem, meropenem, piperacillin-tazobactam, ciprofloxacin, amikacin, and ceftazidime) constituted the study group.
Results.
One hundred and twenty isolates were isolated.
Various risk factors were detected for each antibiotic in the univariate analysis.
In the multivariate analysis, previous cefazolin use was found as an independent risk factor for the development of imipenem resistance (OR = 3.33; CI 95% [1.11–10.0]; p = 0.03), whereas previous cerebrovascular attack (OR = 3.57; CI 95% [1.31–9.76]; p = 0.01) and previous meropenem use (OR = 4.13; CI 95% [1.21–14.07]; p = 0.02) were independent factors for the development of meropenem resistance.
For the development of resistance to ciprofloxacin, hospitalization in the neurology intensive care unit (OR = 4.24; CI 95% [1.5–11.98]; p = 0.006) and mechanical ventilator application (OR = 11.7; CI 95% [2.24–61.45]; p = 0.004) were independent risk factors.
Conclusion.
The meticulous application of contact measures can decrease the rate of nosocomial infections.
American Psychological Association (APA)
Sonmezer, Meliha Cagla& Ertem, Gunay& Erdinc, Fatma Sebnem& Kaya Kilic, Esra& Tulek, N.& Adiloglu, Ali…[et al.]. 2016. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099965
Modern Language Association (MLA)
Sonmezer, Meliha Cagla…[et al.]. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099965
American Medical Association (AMA)
Sonmezer, Meliha Cagla& Ertem, Gunay& Erdinc, Fatma Sebnem& Kaya Kilic, Esra& Tulek, N.& Adiloglu, Ali…[et al.]. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099965