Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis
Joint Authors
Sanaee, Layli
Taljaard, Monica
Karnauchow, Tim
Perry, Jeffrey J.
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
It can be difficult for clinicians to distinguish between the relatively benign enteroviral (EnV) meningitis and potentially lethal herpes simplex virus (HSV) central nervous system (CNS) disease.
Very limited evidence currently exists to guide them.
Objective.
This study sought to identify clinical features and cerebrospinal fluid (CSF) findings associated with HSV CNS disease.
Methods.
Given that PCR testing often is not immediately available, this chart review study sought to identify clinical and cerebrospinal fluid (CSF) findings associated with HSV meningitis over a 6-year period.
In cases where PCR was not performed, HSV and EnV were assigned based on clinical criteria.
Results.
We enrolled 166 consecutive patients: 40 HSV and 126 EnV patients.
HSV patients had a mean 40.4 versus 31.3 years for EnV, p = 0 .
005 , seizures 21.1% versus 1.6% for EnV, p < 0.001 , altered mental status 46.2% versus 3.2% for EnV, p < 0.001 , or neurological deficits 44.7% versus 3.9% for EnV, p < 0.001 .
CSF neutrophils were lower in HSV (median 3.0% versus 9.5%, p = 0 .
0002 ); median lymphocytes (87.0% versus 67.0%, p = 0 .
0004 ) and protein (0.9 g/L versus 0.6 g/L, p = 0 .
0005 ) were elevated.
Conclusion.
Our study found that HSV patients were older and more likely to have seizure, altered mental status, or neurological deficits than patients with benign EnV meningitis.
HSV cases had lower CSF neutrophils, higher lymphocytes, and higher protein levels.
American Psychological Association (APA)
Sanaee, Layli& Taljaard, Monica& Karnauchow, Tim& Perry, Jeffrey J.. 2016. Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099983
Modern Language Association (MLA)
Sanaee, Layli…[et al.]. Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099983
American Medical Association (AMA)
Sanaee, Layli& Taljaard, Monica& Karnauchow, Tim& Perry, Jeffrey J.. Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099983