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Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease
Joint Authors
Yoshida, Eric M.
Azalagara, Vladimir Marquez
Hull, Mark
Maruyama, Anna
Hussaini, Trana
Partovi, Nilufar
Erb, Siegfried R.
Zalunardo, Nadia
Pick, Neora
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Although major advances have occurred in treating patients with hepatitis C virus (HCV) with the development of new direct-acting antivirals (DAAs), treatment of liver transplant recipients with HCV, human immunodeficiency virus (HIV) coinfection, and renal disease is challenging due to the lack of efficacy and safety data in this population.
We report a case of successful HCV therapy in a postliver transplant HIV coinfected patient, with stage 4 chronic kidney disease, using an all-oral regimen of simeprevir, sofosbuvir, and ribavirin.
The 51-year-old male achieved SVR24, and no specific HIV-related or transplant-related adverse events were documented during the treatment period.
The new DAAs show promise for HIV coinfected patients and those with severe to end-stage renal disease (ESRD); however, robust clinical trials or large cohort studies will need to be conducted to confirm the efficacy and safety of these newer agents in this setting.
American Psychological Association (APA)
Maruyama, Anna& Hussaini, Trana& Partovi, Nilufar& Erb, Siegfried R.& Azalagara, Vladimir Marquez& Zalunardo, Nadia…[et al.]. 2016. Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100018
Modern Language Association (MLA)
Maruyama, Anna…[et al.]. Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100018
American Medical Association (AMA)
Maruyama, Anna& Hussaini, Trana& Partovi, Nilufar& Erb, Siegfried R.& Azalagara, Vladimir Marquez& Zalunardo, Nadia…[et al.]. Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100018