Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern
Joint Authors
Jayachandran, Abirami Lakshmy
Katragadda, Radhika
Thyagarajan, Ravinder
Vajravelu, Leela
Manikesi, Suganthi
Kaliappan, Shanmugam
Jayachandran, Balaji
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oropharyngeal candidiasis is one of the common manifestations seen in cancer patients on cytotoxic therapy and invasion into deeper tissues can occur if not treated promptly.
Emergence of antifungal drug resistance is of serious concern owing to the associated morbidity and mortality.
The present study aims at evaluation of clinicomycological association and antifungal drug susceptibility among the 180 recruited patients with cancer on chemotherapy and/or radiotherapy with signs or symptoms suggestive of oral candidiasis.
Speciation and antifungal susceptibility was done by Microbroth dilution method for fluconazole, Itraconazole, and Amphotericin B as per standard microbiological techniques.
Chi-square test was used for statistical analysis ( p < 0.05 was considered statistically significant).
Candida albicans was the predominant species isolated (94) (58%) followed by Candida tropicalis (34) (20.9%).
Fluconazole and Itraconazole showed an overall resistance rate of 14% and 14.8%, respectively.
All the isolates were susceptible to Amphotericin B.
There was a significant association between the presence of dry mouth and isolation of Candida ( p < 0.001 ) .
Such clinicomicrobiological associations can help in associating certain symptoms with the isolation of Candida.
Species level identification with in vitro antifungal susceptibility pattern is essential to choose the appropriate drug and to predict the outcome of therapy.
American Psychological Association (APA)
Jayachandran, Abirami Lakshmy& Katragadda, Radhika& Thyagarajan, Ravinder& Vajravelu, Leela& Manikesi, Suganthi& Kaliappan, Shanmugam…[et al.]. 2016. Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100021
Modern Language Association (MLA)
Jayachandran, Abirami Lakshmy…[et al.]. Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100021
American Medical Association (AMA)
Jayachandran, Abirami Lakshmy& Katragadda, Radhika& Thyagarajan, Ravinder& Vajravelu, Leela& Manikesi, Suganthi& Kaliappan, Shanmugam…[et al.]. Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100021