A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
Joint Authors
Ye, Hanhui
Yuan, Jinjin
Wang, Zhengwu
Huang, Aiqiong
Liu, Xiaolong
Han, Xiao
Chen, Yahong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome.
Studies on the interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS disease.
To resolve more genetic factors related to AIDS, a canonical correlation analysis was used to determine the correlation between AIDS restriction and metabolic pathway gene expression.
The results show that HIV-1 postentry cellular viral cofactors from AIDS restriction genes are coexpressed in human transcriptome microarray datasets.
Further, the purine metabolism pathway comprises novel host factors that are coexpressed with AIDS restriction genes.
Using a canonical correlation analysis for expression is a reliable approach to exploring the mechanism underlying AIDS.
American Psychological Association (APA)
Ye, Hanhui& Yuan, Jinjin& Wang, Zhengwu& Huang, Aiqiong& Liu, Xiaolong& Han, Xiao…[et al.]. 2016. A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1100079
Modern Language Association (MLA)
Ye, Hanhui…[et al.]. A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1100079
American Medical Association (AMA)
Ye, Hanhui& Yuan, Jinjin& Wang, Zhengwu& Huang, Aiqiong& Liu, Xiaolong& Han, Xiao…[et al.]. A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1100079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100079