Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study
Joint Authors
Zang, Yunliang
Gong, Yinglan
Dai, Ling
Xia, Ling
Zheng, Dingchang
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Early afterdepolarization (EAD) plays an important role in arrhythmogenesis.
Many experimental studies have reported that Ca2+/calmodulin-dependent protein kinase II (CaMKII) and β-adrenergic signaling pathway are two important regulators.
In this study, we developed a modified computational model of human ventricular myocyte to investigate the combined role of CaMKII and β-adrenergic signaling pathway on the occurrence of EADs.
Our simulation results showed that (1) CaMKII overexpression facilitates EADs through the prolongation of late sodium current’s (INaL) deactivation progress; (2) the combined effect of CaMKII overexpression and activation of β-adrenergic signaling pathway further increases the risk of EADs, where EADs could occur at shorter cycle length (2000 ms versus 4000 ms) and lower rapid delayed rectifier K+ current (IKr) blockage (77% versus 85%).
In summary, this study computationally demonstrated the combined role of CaMKII and β-adrenergic signaling pathway on the occurrence of EADs, which could be useful for searching for therapy strategies to treat EADs related arrhythmogenesis.
American Psychological Association (APA)
Dai, Ling& Zang, Yunliang& Zheng, Dingchang& Xia, Ling& Gong, Yinglan. 2016. Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100134
Modern Language Association (MLA)
Dai, Ling…[et al.]. Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1100134
American Medical Association (AMA)
Dai, Ling& Zang, Yunliang& Zheng, Dingchang& Xia, Ling& Gong, Yinglan. Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100134