Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection
Joint Authors
Anderson, Christopher S.
DeDiego, Marta L.
Topham, David J.
Thakar, Juilee
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systems virology integrates host-directed approaches with molecular profiling to understand viral pathogenesis.
Self-contained statistical approaches that combine expression profiles of genes with the available databases defining the genes involved in the pathways (gene-sets) have allowed characterization of predictive gene-signatures associated with outcome of the influenza virus (IV) infection.
However, such enrichment techniques do not take into account interactions among pathways that are responsible for the IV infection pathogenesis.
We investigate dendritic cell response to seasonal H1N1 influenza A/New Caledonia/20/1999 (NC) infection and infer the Boolean logic rules underlying the interaction network of ligand induced signaling pathways and transcription factors.
The model reveals several novel regulatory modes and provides insights into mechanism of cross talk between NFκB and IRF mediated signaling.
Additionally, the logic rule underlying the regulation of IL2 pathway that was predicted by the Boolean model was experimentally validated.
Thus, the model developed in this paper integrates pathway analysis tools with the dynamic modeling approaches to reveal the regulation between signaling pathways and transcription factors using genome-wide transcriptional profiles measured upon influenza infection.
American Psychological Association (APA)
Anderson, Christopher S.& DeDiego, Marta L.& Topham, David J.& Thakar, Juilee. 2016. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1100197
Modern Language Association (MLA)
Anderson, Christopher S.…[et al.]. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1100197
American Medical Association (AMA)
Anderson, Christopher S.& DeDiego, Marta L.& Topham, David J.& Thakar, Juilee. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1100197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100197