The association of TSHR gene rs2268458 polymorphism with hypothyroidism in females of Babylon province-Iraq
Joint Authors
al-Harbi, Husayn Jasim Ubayd
Husayn, Batul Ibrahim
Hadi, Maysaa Adil
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 8 (31 Aug. 2018), pp.7-18, 12 p.
Publisher
Publication Date
2018-08-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
The Aim: To evaluate the association of TSHR gene polymorphism rs2268458 with some Physio-biochemical parameters among hypothyroidism women.
Methods: This study included 51 hypothyroidism women and 43 healthy women as a control group.
Some Physio- biochemical (body mass index (BMI), cytochrome 450 1A1 (CYP1A1), calcium, and phosphorus) and hormonal assay (Osteopontin (OPN), thyroid stimulating hormone (TSH), fT3, fT4 and Calcitonin (CT)) assay were performed.
Genotyping of rs-2268458 of TSHR gene was carried out using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique.
Results: TSHR rs2268458 was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for disease by OR= 4.393, CI=1.42-13.53 where TC and CC genotypes were associated with high BMI, while TC genotype was associated with high calcitonin and CYP1A1 levels.
Conclusion: The TSHR rs2268458 polymorphism was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for some Physio-biochemical and hormonal disorder in hypothyroidism women.
American Psychological Association (APA)
Husayn, Batul Ibrahim& Hadi, Maysaa Adil& al-Harbi, Husayn Jasim Ubayd. 2018. The association of TSHR gene rs2268458 polymorphism with hypothyroidism in females of Babylon province-Iraq. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 8, pp.7-18.
https://search.emarefa.net/detail/BIM-1100229
Modern Language Association (MLA)
Husayn, Batul Ibrahim…[et al.]. The association of TSHR gene rs2268458 polymorphism with hypothyroidism in females of Babylon province-Iraq. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 8 (2018), pp.7-18.
https://search.emarefa.net/detail/BIM-1100229
American Medical Association (AMA)
Husayn, Batul Ibrahim& Hadi, Maysaa Adil& al-Harbi, Husayn Jasim Ubayd. The association of TSHR gene rs2268458 polymorphism with hypothyroidism in females of Babylon province-Iraq. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 8, pp.7-18.
https://search.emarefa.net/detail/BIM-1100229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 16-18
Record ID
BIM-1100229