Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice
Joint Authors
Gong, Hai-Qing
Liang, Pei-Ji
Zhang, Pu-Ming
Lu, Qin-Chi
Zhang, Zhen
Li, Jia-Jia
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The thalamus and hippocampus have been found both involved in the initiation, propagation, and termination of temporal lobe epilepsy.
However, the interaction of these regions during seizures is not clear.
The present study is to explore whether some regular patterns exist in their interaction during the termination of seizures.
Multichannel in vivo recording techniques were used to record the neural activities from the cornu ammonis 1 (CA1) of hippocampus and mediodorsal thalamus (MDT) in mice.
The mice were kindled by electrically stimulating basolateral amygdala neurons, and Racine’s rank standard was employed to classify the stage of behavioral responses (stage 1~5).
The coupling index and directionality index were used to investigate the synchronization and information flow direction between CA1 and MDT.
Two main results were found in this study.
(1) High levels of synchronization between the thalamus and hippocampus were observed before the termination of seizures at stage 4~5 but after the termination of seizures at stage 1~2.
(2) In the end of seizures at stage 4~5, the information tended to flow from MDT to CA1.
Those results indicate that the synchronization and information flow direction between the thalamus and the hippocampus may participate in the termination of seizures.
American Psychological Association (APA)
Zhang, Zhen& Li, Jia-Jia& Lu, Qin-Chi& Gong, Hai-Qing& Liang, Pei-Ji& Zhang, Pu-Ming. 2016. Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1100240
Modern Language Association (MLA)
Zhang, Zhen…[et al.]. Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1100240
American Medical Association (AMA)
Zhang, Zhen& Li, Jia-Jia& Lu, Qin-Chi& Gong, Hai-Qing& Liang, Pei-Ji& Zhang, Pu-Ming. Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1100240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100240