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High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy
Joint Authors
Lee, Alex T.
Barnes, Christopher R.
Jain, Shweta
Pauldine, Ronald
Source
Case Reports in Anesthesiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The antifibrinolytic agent ε-aminocaproic acid is used to decrease procedural blood loss in a variety of high risk surgeries.
The utility of recombinant factor VII administration in massive hemorrhage has also been reported in a variety of settings, though the impact in a surgical context remains unclear.
We describe the case of a patient who underwent massive open splenectomy and developed diffuse retroperitoneal bleeding on postoperative day one.
Massive transfusion was initiated, but attempts to control hemorrhage with surgical and interventional radiology approaches were unsuccessful, as was recombinant factor VII administration.
Commencement of a high dose aminocaproic acid infusion was followed by a prominent rise in fibrinogen levels and stabilization of the hemorrhage.
Indications, dosages, and adverse effects of ε-aminocaproic acid as described in the literature are reviewed.
American Psychological Association (APA)
Lee, Alex T.& Barnes, Christopher R.& Jain, Shweta& Pauldine, Ronald. 2016. High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy. Case Reports in Anesthesiology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100253
Modern Language Association (MLA)
Lee, Alex T.…[et al.]. High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy. Case Reports in Anesthesiology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100253
American Medical Association (AMA)
Lee, Alex T.& Barnes, Christopher R.& Jain, Shweta& Pauldine, Ronald. High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy. Case Reports in Anesthesiology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100253