Paliperidone Inducing Concomitantly Syndrome of Inappropriate Antidiuretic Hormone, Neuroleptic Malignant Syndrome, and Rhabdomyolysis
Joint Authors
Kaur, Jaspinder
Sachmechi, Issac
Alfishawy, Mostafa
Kumar, Dileep
Lopez, Ricardo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Paliperidone, an active metabolite of risperidone, is a new atypical antipsychotic agent.
Syndrome of inappropriate antidiuretic hormone (SIADH), neuroleptic malignant syndrome (NMS), and rhabdomyolysis are the uncommon side effects of psychotropic drugs.
We report a case of 35-year-old male with schizoaffective disorder who was admitted for acute-on-chronic exacerbation of his psychotic disorder for which intramuscular paliperidone 234 mg injection was given.
Two days later, the patient developed hyponatremic seizures secondary to SIADH which was treated with hypertonic saline.
On the third day, he developed high grade fever and severe muscle rigidity with raised creatine phosphokinase (CPK) and liver enzymes levels.
He was treated with dantrolene 100 mg, bromocriptine 2.5 mg, and lorazepam 2 mg.
Our patient required management of the three rare conditions following treatment with paliperidone.
This case highlights the need for health care providers to be aware of the rare, potentially life threatening but preventable hyponatremia, NMS, and rhabdomyolysis as a possible adverse effect of paliperidone.
American Psychological Association (APA)
Kaur, Jaspinder& Kumar, Dileep& Alfishawy, Mostafa& Lopez, Ricardo& Sachmechi, Issac. 2016. Paliperidone Inducing Concomitantly Syndrome of Inappropriate Antidiuretic Hormone, Neuroleptic Malignant Syndrome, and Rhabdomyolysis. Case Reports in Critical Care،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100426
Modern Language Association (MLA)
Kaur, Jaspinder…[et al.]. Paliperidone Inducing Concomitantly Syndrome of Inappropriate Antidiuretic Hormone, Neuroleptic Malignant Syndrome, and Rhabdomyolysis. Case Reports in Critical Care No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1100426
American Medical Association (AMA)
Kaur, Jaspinder& Kumar, Dileep& Alfishawy, Mostafa& Lopez, Ricardo& Sachmechi, Issac. Paliperidone Inducing Concomitantly Syndrome of Inappropriate Antidiuretic Hormone, Neuroleptic Malignant Syndrome, and Rhabdomyolysis. Case Reports in Critical Care. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100426