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Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery
Joint Authors
Thompson Bastin, Melissa L.
Parli, Sara E.
Lewis, Daniel A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To report the ability to remove serum dabigatran using continuous renal replacement therapy (CRRT) in a patient with life-threatening bleeding.
Summary.
A 77-year-old female with history of atrial fibrillation who takes dabigatran for stroke prevention presented with abdominal pain.
Patient was found to have bleeding and possible mesenteric ischemia and was taken to the operating room and had continued bleeding postoperatively.
CRRT was initiated for the removal of any remaining dabigatran, with serum dabigatran levels collected to evaluate removal of dabigatran with CRRT.
This patient had an increased dabigatran level prior to intervention, which decreased to an undetectable level after use of CRRT.
Greater than 80% of the drug was removed due to 4 hours of CRRT and residual kidney function.
Reversal of dabigatran is an area of current research with recent FDA approval of idarucizumab for use.
Conclusion.
Bleeding may occur as a result of the use of dabigatran and change in patient’s clinical condition.
Use of CRRT may be an option in removing serum dabigatran in the case of a life-threatening bleed.
American Psychological Association (APA)
Parli, Sara E.& Thompson Bastin, Melissa L.& Lewis, Daniel A.. 2016. Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery. Case Reports in Critical Care،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100460
Modern Language Association (MLA)
Parli, Sara E.…[et al.]. Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery. Case Reports in Critical Care No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100460
American Medical Association (AMA)
Parli, Sara E.& Thompson Bastin, Melissa L.& Lewis, Daniel A.. Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery. Case Reports in Critical Care. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100460