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Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure
Joint Authors
Träger, Karl
Schütz, Christian
Fischer, Günther
Schröder, Janpeter
Skrabal, Christian
Liebold, Andreas
Reinelt, Helmut
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 45-year-old male was admitted to our hospital with a small bowel obstruction due to torsion and was immediately scheduled for surgical intervention.
At anesthesia induction, the patient aspirated and subsequently developed a severe SIRS with ARDS and multiple organ failure requiring the use of ECMO, CRRT, antibiotics, and low dose steroids.
Due to a rapid deterioration in clinical status and a concurrent surge in inflammatory biomarkers, an extracorporeal cytokine adsorber (CytoSorb) was added to the CRRT blood circuit.
The combined treatment resulted in a rapid and significant reduction in the levels of circulating inflammatory mediators.
This decrease was paralleled by marked clinical stabilization of the patient including a significant improvement in hemodynamic stability and a reduced need for norepinephrine and improved respiratory function as measured by PaO2/FIO2, ventilator parameters, lung mechanics, and indirect measures of capillary leak syndrome.
The patient could be discharged to a respiratory weaning unit where successful respiratory weaning could be achieved later on.
We attribute the clinical improvement to the rapid control of the hyperinflammatory response and the reduction of inflammatory mediators using a combination of CytoSorb and these other therapies.
CytoSorb treatment was safe and well tolerated, with no device-related adverse effects observed.
American Psychological Association (APA)
Träger, Karl& Schütz, Christian& Fischer, Günther& Schröder, Janpeter& Skrabal, Christian& Liebold, Andreas…[et al.]. 2016. Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure. Case Reports in Critical Care،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100462
Modern Language Association (MLA)
Träger, Karl…[et al.]. Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure. Case Reports in Critical Care No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100462
American Medical Association (AMA)
Träger, Karl& Schütz, Christian& Fischer, Günther& Schröder, Janpeter& Skrabal, Christian& Liebold, Andreas…[et al.]. Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure. Case Reports in Critical Care. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100462