Nonsuppressible Oral Dexamethasone Suppression Tests but Not Cushing Syndrome
Joint Authors
Nair, Abilash
Dhingra, Atul
Gopi, Anjana
Jyotsna, Viveka P.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
In spite of the presence of definitive diagnostic criteria to diagnose Cushing syndrome diagnosis may become challenging.
We report a young female with mild clinical features of Cushing syndrome, who had nonsuppressible oral dexamethasone suppression tests; also she had a suspicious pituitary lesion.
She underwent pituitary surgery and a pituitary microadenoma (non-ACTH staining) was removed.
Now she had come to us with similar complaints to those before.
Again she had nonsuppressible oral dexamethasone suppression tests.
As the diurnal variation of serum and salivary cortisol was maintained and urinary free cortisol was normal, further evaluation with IV dexamethasone suppression test was performed which clearly ruled out Cushing syndrome.
The patient was not on any medicines known to alter dexamethasone metabolism.
Fat malabsorption was also ruled out using appropriate tests.
The reason for this discrepancy is thought to be altered (increased) metabolism of dexamethasone in this patient as it is widely variable in the general population.
American Psychological Association (APA)
Nair, Abilash& Dhingra, Atul& Gopi, Anjana& Jyotsna, Viveka P.. 2016. Nonsuppressible Oral Dexamethasone Suppression Tests but Not Cushing Syndrome. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100683
Modern Language Association (MLA)
Nair, Abilash…[et al.]. Nonsuppressible Oral Dexamethasone Suppression Tests but Not Cushing Syndrome. Case Reports in Endocrinology No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1100683
American Medical Association (AMA)
Nair, Abilash& Dhingra, Atul& Gopi, Anjana& Jyotsna, Viveka P.. Nonsuppressible Oral Dexamethasone Suppression Tests but Not Cushing Syndrome. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100683