Acute Kidney Injury Associated with Linagliptin
Joint Authors
Nandikanti, Deepak K.
Gosmanova, Elvira O.
Gosmanov, Aidar R.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-14
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Linagliptin is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that is approved for the treatment of type 2 diabetes mellitus.
About 5% of linagliptin is eliminated by the kidneys and no dose adjustment is recommended in kidney impairment.
We report a first case of linagliptin-associated acute kidney injury (AKI) in a patient with preexisting chronic kidney disease (CKD).
We hypothesize that AKI was due to renal hypoperfusion from linagliptin-induced natriuresis and intravascular volume contraction in the setting of concomitant lisinopril use, which is known to impair autoregulation and potentiate hypotension-induced AKI.
It may be prudent to exert caution and closely monitor kidney function when initiating linagliptin in combination with ACE-inhibitors in CKD patients.
American Psychological Association (APA)
Nandikanti, Deepak K.& Gosmanova, Elvira O.& Gosmanov, Aidar R.. 2016. Acute Kidney Injury Associated with Linagliptin. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-2.
https://search.emarefa.net/detail/BIM-1100691
Modern Language Association (MLA)
Nandikanti, Deepak K.…[et al.]. Acute Kidney Injury Associated with Linagliptin. Case Reports in Endocrinology No. 2016 (2016), pp.1-2.
https://search.emarefa.net/detail/BIM-1100691
American Medical Association (AMA)
Nandikanti, Deepak K.& Gosmanova, Elvira O.& Gosmanov, Aidar R.. Acute Kidney Injury Associated with Linagliptin. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-2.
https://search.emarefa.net/detail/BIM-1100691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100691
