Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review
Joint Authors
Anyfantakis, Anastasios
Vourliotaki, Irene
Anyfantakis, Dimitrios
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Resistance to thyroid hormone (RTH) is an extremely rare dominantly inherited condition of impaired tissue responsiveness to thyroid hormone (TH).
Most patients with RTH have mutations in the gene that encodes the β isoform of the receptor of thyroid hormone (THR-β gene).
Mutant receptors are unable to activate or repress target genes.
The majority of them are asymptomatic or rarely have hypo- or hyperthyroidism.
RTH is suspected by the finding of persistent elevation of serum levels of free T3 (FT3) and free T4 (FT4) and nonsuppressed TSH.
We present two cases of RTH diagnosed after total thyroidectomy.
The first patient was initially diagnosed with primary hyperthyroidism due to toxic multinodular goiter.
The second patient had undergone thyroidectomy for multinodular goiter 16 years before diagnosis of RTH.
After thyroidectomy, although on relatively high doses of levothyroxine, both of them presented with the laboratory findings of RTH.
Genetic analysis revealed RTH.
American Psychological Association (APA)
Anyfantakis, Anastasios& Anyfantakis, Dimitrios& Vourliotaki, Irene. 2016. Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100704
Modern Language Association (MLA)
Anyfantakis, Anastasios…[et al.]. Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review. Case Reports in Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100704
American Medical Association (AMA)
Anyfantakis, Anastasios& Anyfantakis, Dimitrios& Vourliotaki, Irene. Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100704