The Use of Plasma-Derived Complement C1-Esterase Inhibitor Concentrate (Berinert®)‎ in the Treatment of Angiotensin Converting Enzyme-Inhibitor Related Angioedema

Abstract EN

Angioedema of the upper airways is a severe and potentially life-threatening condition.

The incidence has been increasing in the past two decades, primarily due to pharmaceuticals influencing the generation or degradation of the vasoactive molecule bradykinin.

Plasma-derived C1-esterase inhibitor concentrate is a well-established treatment option of hereditary and acquired complement C1-esterase inhibitor deficiency, which are also mediated by an increased level of bradykinin resulting in recurrent angioedema.

We here present a case of severe angiotensin converting enzyme-inhibitor related angioedema (ACEi-AE) of the hypopharynx that completely resolved rapidly after the infusion of plasma-derived C1-inhibitor concentrate adding to the sparse reports in the existing literature.