Seronegative Intestinal Villous Atrophy: A Diagnostic Challenge
Joint Authors
Martins, Cláudio
Teixeira, Cristina
Ribeiro, Suzane
Trabulo, Daniel
Cardoso, Cláudia
Mangualde, João
Freire, Ricardo
Alves, Ana Luísa
Gamito, Élia
Cremers, Isabelle
Oliveira, Ana Paula
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Celiac disease is the most important cause of intestinal villous atrophy.
Seronegative intestinal villous atrophy, including those that are nonresponsive to a gluten-free diet, is a diagnostic challenge.
In these cases, before establishing the diagnosis of seronegative celiac disease, alternative etiologies of atrophic enteropathy should be considered.
Recently, a new clinical entity responsible for seronegative villous atrophy was described—olmesartan-induced sprue-like enteropathy.
Herein, we report two uncommon cases of atrophic enteropathy in patients with arterial hypertension under olmesartan, who presented with severe chronic diarrhea and significant involuntary weight loss.
Further investigation revealed intestinal villous atrophy and intraepithelial lymphocytosis.
Celiac disease and other causes of villous atrophy were ruled out.
Drug-induced enteropathy was suspected and clinical improvement and histologic recovery were verified after olmesartan withdrawal.
These cases highlight the importance for clinicians to maintain a high index of suspicion for olmesartan as a precipitant of sprue-like enteropathy.
American Psychological Association (APA)
Martins, Cláudio& Teixeira, Cristina& Ribeiro, Suzane& Trabulo, Daniel& Cardoso, Cláudia& Mangualde, João…[et al.]. 2016. Seronegative Intestinal Villous Atrophy: A Diagnostic Challenge. Case Reports in Gastrointestinal Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100805
Modern Language Association (MLA)
Martins, Cláudio…[et al.]. Seronegative Intestinal Villous Atrophy: A Diagnostic Challenge. Case Reports in Gastrointestinal Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100805
American Medical Association (AMA)
Martins, Cláudio& Teixeira, Cristina& Ribeiro, Suzane& Trabulo, Daniel& Cardoso, Cláudia& Mangualde, João…[et al.]. Seronegative Intestinal Villous Atrophy: A Diagnostic Challenge. Case Reports in Gastrointestinal Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100805